Research Article
17 June 1996
Free access

Control of expression of the I factor, a LINE‐like transposable element in Drosophila melanogaster.

The EMBO Journal
(1996)
15: 3174 - 3181
I factors are LINE‐like transposable elements in the genome of Drosophila melanogaster. They normally transpose infrequently but are activated in the germline of female progeny of crosses between males of a strain that contains complete elements, an I or inducer strain and females of a strain that does not, an R or reactive strain. This causes a phenomenon known as I‐R hybrid dysgenesis. We have previously shown that the I factor promoter lies between nucleotides 1 and 30. Here we demonstrate that expression of this promoter is regulated by nucleotides 41–186 of the I factor. This sequence can act as an enhancer as it stimulates expression of the hsp7O promoter in ovaries in the absence of heat‐shock. Within this region there is a site that is required for promoter activity and that is recognized by a sequence‐specific binding protein. We propose that this protein contributes to the enhancer activity of nucleotides 41–186 and that reduced I factor expression in inducer strains is due to titration of this protein or others that interact with it.

Formats available

You can view the full content in the following formats:

Information & Authors

Information

Published In

The EMBO Journal cover image
The EMBO Journal
Vol. 15 | No. 12
June 1996
Table of contents
Pages: 3174 - 3181

Submission history

Published in issue: June 1996
Published online: 17 June 1996

Permissions

Request permissions for this article.

Authors

Affiliations

A. Udomkit
Institute of Cell and Molecular Biology, University of Edinburgh, UK.
S. Forbes
Institute of Cell and Molecular Biology, University of Edinburgh, UK.
C. McLean
Institute of Cell and Molecular Biology, University of Edinburgh, UK.
I. Arkhipova
Institute of Cell and Molecular Biology, University of Edinburgh, UK.
D. J. Finnegan
Institute of Cell and Molecular Biology, University of Edinburgh, UK.

Metrics & Citations

Metrics

Citations

Download Citations

If you have the appropriate software installed, you can download article citation data to the citation manager of your choice. Select your manager software from the list below and click Download.

Citing Literature

View Options

View options

PDF

View PDF

Figures

Tables

Media

Share

Share

Copy the content Link

Share on social media