Control of expression of the I factor, a LINE‐like transposable element in Drosophila melanogaster.
The EMBO Journal
(1996)
15: 3174 - 3181
I factors are LINE‐like transposable elements in the genome of Drosophila melanogaster. They normally transpose infrequently but are activated in the germline of female progeny of crosses between males of a strain that contains complete elements, an I or inducer strain and females of a strain that does not, an R or reactive strain. This causes a phenomenon known as I‐R hybrid dysgenesis. We have previously shown that the I factor promoter lies between nucleotides 1 and 30. Here we demonstrate that expression of this promoter is regulated by nucleotides 41–186 of the I factor. This sequence can act as an enhancer as it stimulates expression of the hsp7O promoter in ovaries in the absence of heat‐shock. Within this region there is a site that is required for promoter activity and that is recognized by a sequence‐specific binding protein. We propose that this protein contributes to the enhancer activity of nucleotides 41–186 and that reduced I factor expression in inducer strains is due to titration of this protein or others that interact with it.
Formats available
You can view the full content in the following formats:
Information & Authors
Information
Published In

Submission history
Published in issue: June 1996
Published online: 17 June 1996
Copyright
© 1996 European Molecular Biology Organization.
Authors
Metrics & Citations
Metrics
Citations
Download Citations
If you have the appropriate software installed, you can download article citation data to the citation manager of your choice. Select your manager software from the list below and click Download.