Iburg at al develop a high-throughput in vivo screen to construct a comprehensive map of the interactions among all 11 proteins of the pNL29 gas vesicle operon.

Significant advances in structural and biochemical research validate the 9-year-old hypothesis that cardiac hypercontractility seen in patients with hypertrophic cardiomyopathy is primarily caused by sarcomeric mutations that increase the number of myosin molecules available for actin interaction.

Swi5-Sfr1 restriction ensures homolog invasions are dismantled in a timely manner to guarantee proper chromosome distribution and faithful genome transmission into the meiotic products.

Two recent articles reveal that leftover replisome impede the next round of replication, and how specific helicases can help to overcome this problem.

Novel p53 knock-in and p53 target gene mouse strains enable interaction proteomics, DNA binding studies, as well as the imaging of p53 contributions to cell cycle arrest and apoptosis in situ.

Insulin-responsive GLUT4 secretion requires a designated clathrin isoform, CHC22, which is specifically recruited through its interactions with the trafficking proteins p115 and SNX5.

Combined with proteomics and quantitative lipidomics, this method for purification of specific yeast membranes establishes molecular fingerprints of membrane-based forms of endoplasmic reticulum (ER) stress.

Standard cell culture medium volumes dictate a hypoxic pericellular in vitro microenvironment due to oxygen consumption exceeding diffusion rates.

Genome-wide i-motif immunoprecipitation and next-generation sequencing shows that sequences capable of forming these knot-like DNA structures are widely distributed and common in G0/G1-expressed genes.

As part of a metabolism methods advice series, this commentary highlights frequent pitfalls and offers guidance related to designing, processing, and communicating metabolomics analyses.

A user-friendly predictor correlates propensity for phase separation with key biophysical features, and can be applied to study phytobacterial type III effectors.

Maternally inherited H3K9me3 guides HP1a clustering in early embryos and is essential for early fly embryogenesis.

This review summarises emerging views on how differentiated cells become cancer cells and contribute to malignancies due to accumulating mutations, aberrant tissue repair programs and hijacked cell state plasticity.

Hab1 is a novel autophagy receptor in yeast which targets ribosome for degradation by autophagy.