This review discusses the progressive uncoupling of transcriptomes and proteomes during healthy aging, and the underlying mechanisms of translation, mRNA and RNP regulation in various model organisms.

This review discusses the crosstalk between the central nervous system and the adipose tissue, focusing on how this bidirectional signaling regulates metabolic functions.

The transition from postdoc to PI is the most challenging career step. Peer groups, PIs and research institution can help postdocs to acquire the necessary skills and experience.

A UDR motif in DNMT3A acts in concert with other chromatin reading regions to promote chromatin recruitment. A cryo-EM structure reveals that DNMT3A1 binds to H2AK119ub-marked nucleosomes through its UDR motif, although this mark does not enhance DNA methylation activity.

The winter holidays are a time to celebrate, but can be oppressive for those who cannot. It is therefore important to look after trainees and colleagues who miss their loved ones on Christmas day.

PTGS facilitates but is not required for the de novo epigenetic silencing of EVD, a proliferative retrotransposon in Arabidopsis.

Photo-crosslinking represents a novel way to study protein-protein interactions in immune receptors. Using this technique, this study shows that the extracellular regions of the TCR–CD3 complex do not undergo large conformational changes to propagate activation signaling.

A deubiquitinase complex consisting of USP12/46-WDR48-WDR20 deubiquitinates the cytoplasmic domains of integrins and numerous additional cell surface proteins at early endosomes, which prevents their ESCRT-mediated lysosomal degradation and promotes their recycling back to the cell surface.

The geroscience research program of the last decade has entailed a shift of focus in research on aging, away from understanding its underlying biology and towards translation into anti-aging treatments—a shift that is premature.

Plants have evolved specific immune responses to directly suppress infiltrated pathogens. This review summarizes our current understanding of how plant immunity controls pathogen growth and behavior and highlights outstanding questions on pathogen suppression.

Combinational degron technologies with AID2 and BromoTag allow for inducing independent degradation of two proteins or enhancing target depletion. Co-depletion of ORC1 and CDC6 with an AID2-BromoTag double-degron system results in mitotic entry without DNA replication.

The move to Open Access publishing and the diminishing weight of the Impact Factor has unintended and even negative consequences.

DNA-PKcs has a role in neuronal plasticity via PSD-95 phosphorylation and regulation of its protein stability, revealing a physiological role beyond its function in DNA repair.

Two-photon imaging reveals the spatiotemporal regulation of pollen tube guidance based on multistep blocking systems to prevent polyspermy.

The actin monomer binding protein profilin 1 (PFN1) localizes inside mitochondria and has important roles in maintaining mitochondrial homeostasis.

Nup358-positive annulate lamellae (AL) structures are present at ER-mitochondria contact sites (ERMCSs). Nup358 restricts growth factor mediated stabilization of ERMCSs by modulating mTORC2/Akt/GSK3β pathway.

The fate of GM crops in Italy—from endorsement to rejection back to wary acceptance—may hold lessons for other EU member states’ policies on biotechnology.

The mapping of the Drosophila neural connectome is a scientific tour de force. But could bacterial communication be just as sophisticated?

To meet the growing deluge of misinformation and distortion of scientific facts, science desperately needs a PR makeover.

The transition from postdoc to PI is the most challenging career step. Peer groups, PIs and research institution can help postdocs to acquire the necessary skills and experience.

The winter holidays are a time to celebrate, but can be oppressive for those who cannot. It is therefore important to look after trainees and colleagues who miss their loved ones on Christmas day.

Academic research and selection panels need to deal with the problem of predatory journals as these are slowly but inevitably poisoning the scientific record.

The recent rejection of lecanemab by the European Medicines Agency despite its approval in other countries highlights the debate among researchers and regulatory bodies about the efficacy, safety, and underlying scientific basis of drugs to treat Alzheimer’s disease.

Towards the 10th anniversary of the Nagoya Protocol, it is time to embrace key technology developments and adapt existing red tape for genomic monitoring.

Can the scientific literature act as a guide to how social media might self-regulate?

Michael Bronstein outlines his vision for the new Aithyra Institute, which aims to transform biological sciences using AI, with a focus on developing novel approaches to data collection, model training, and hypothesis generation to advance research and improve human health.