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This month's cover highlights the article A split intein and split luciferase-coupled system for detecting protein-protein interactions by Igor Stagljar, Zhong Yao and colleagues. Peptide tags derived from tripartite NanoLuciferase are incorporated into the revised Split Intein-Mediated Protein Ligation assay (SIMPL2). Interaction-induced splicing leads to the reconstitution of luciferase, enabling easy and sensitive detection of protein-protein interactions.
Cover concept by the authors; scientific illustration by SciStories