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This month's cover highlights the article Host inflammatory dynamics reveal placental immune modulation by Group B Streptococcus during pregnancy by Itai Yanai and colleagues. Analyses of placental responses in an ascending infection model reveal that mice infected with a Group B Streptococcus (GBS) toxin knockout strain show a milder tissue-level phenotype but their innate immune cells exhibit more inflammation than wildtype GBS-infected counterparts. (Adapted from Gustav Klimt 'Hope II', 1907; scientific illustration by DrawImpacts)
Mice lacking disease-mutated FBXL4 exhibit loss of mitochondria and perinatal lethality due to excessive basal mitophagy.
IFITM3 limits severity of SARS-CoV-2 infections by restricting viral replication and spread, thereby reducing lung inflammation, immune cell infiltration, angiogenesis, and pathology. IFITM3 KO mice are a new model for studying severe SARS-CoV-2 infections.
An integrative approach using crosslinking mass spectrometry (MS), co-fractionation MS, and AlphaFold-Multimer discovers novel protein complexes and their topologies in the model Gram-positive bacterium Bacillus subtillis.
The analyses of RANK and RANKL expression in large cohorts of breast cancer samples and functional studies in RANK+ breast cancer patient-derived xenografts (PDXs) revealed a key role for RANK in postmenopausal women with estrogen receptor negative ER- breast cancer.