The liver function in post-cardiac arrest brain injury is not known and was investigated in a pig model of global cerebral ischemia.

Persistent malaria parasites bridge transmission seasons months apart. Whether plasma composition is seasonally affected, allowing P. falciparum to adjust to serological cues; or if duration of infection dictates clinical presentation and persistence was investigated in a cohort of Malian children.

This Review discusses challenges in developing malaria vaccines and promising recent developments in whole-sporozoite vaccines using genetically engineered parasites with a perspective on future directions of these vaccines for the prevention of malaria.

Effective vaccines and anti-viral drugs against dengue are limited. Our study identifies a small molecule, namely 7D as a stimulator of IFNα/β/λ synthesis, and also booster for neutralizing-antibody generation, capable of protecting dengue infection in 3 different mice models.

CRISPR-based diagnostics have the potential to increase the accessibility of genotyping for pathogenic variants due to its fast and user-friendly nature which enables on-site testing without elaborate machinery. The multiplexed CRISPR assay reported detects two variants in the APOL1 gene relevant for kidney disease and transplantation.

The gut microbiota and its functional metabolites play crucial roles in the development of intestinal fibrosis in patients with Crohn’s disease (CD).

FAO is catalyzed by the mitochondrial trifunctional protein (MTP) and, if overloaded, generates ROS. ROS are boosted during stressful events, favoring cardiac maladaptive remodeling. Melusin is a muscle-specific chaperone able to sustain heart resilience during a wide variety of stressful insults.

Favorable safety profiles and persistent clinical improvements were observed in two patients with highly relapsed and refractory MG over 18 months after BCMA-targeting CAR-T therapy. Distinct characteristics of CAR-T cells in patients with MG were investigated by longitudinal single-cell analysis.

Genome-wide CRISPR screens revealed PKMYT1 as a genetic vulnerability for PDAC. Pharmacological inhibition of PKMYT1 was identified as a new therapeutic strategy for PKMYT1-expressing PDAC patients.

In this review, A. Xu & colleagues describe the molecular pathways whereby exerkine networks mediate the cardiometabolic adaptations to exercise and discuss the potential translation of exerkine-based discovery into therapeutic application and personalized medicine.

Necroptotic cell death is broadly linked to inflammation-associated diseases such as IBD. But, accurately identifying when and where necroptosis occurs in human disease has proven difficult. Using new methods to detect the key regulators of necroptosis - Caspase-8, RIPK1, RIPK3, MLKL - we find that:

In the circulation, platelets interact with blood monocytes enhancing their inflammatory capacity. Platelets are enriched in transcriptional regulators that support human monocyte inflammation. Thrombocytopenia, experimentally induced or as a result of autoimmune disease, renders monocytes anergic to immune stimulation, a state known as immunoparalysis, which weakens host defense programs and increases susceptibility to infection.

The availability of intracellular polyunsaturated fatty acids depends on FADS1/2 desaturases, expressed at higher levels in aggressive triple-negative breast cancers highly susceptible to ferroptosis.

The fat mass and obesity-associated (FTO) protein, an N⁶-methyladenosine (m⁶A) demethylase, influences endothelial cell (EC) function and retinal homeostasis in diabetic retinopathy (DR), thus providing a promising nanotherapeutic approach for DR.

Angiogenesis supports tumor growth. Current antiangiogenic therapies have not significantly improved survival; there is a critical need for new approaches. Mechanisms that regulate transition from normal to tumor-associated endothelial cells and drive pathological angiogenesis are poorly understood.