Chronic nitric oxide (NO) donor treatment is a novel antiepileptic strategy that has an effect beyond neuronal ion channels.

In this review, G. Panagiotou and colleagues discuss the interplay between diet and gut microbiome in the pathogenesis and prevention of early-onset CRC (EO-CRC) and suggest directions for future research that could lead to new preventive and therapeutic approaches.

In this study a novel clinical candidate is introduced as a potent inhibitor of the NLRP3 inflammasome. The chemical diversification of this molecule from existing clinical candidates opens newer avenues for clinical development.

In this Correspondence, P. Pelegrin and colleagues found that the deposition of amyloid in tissues in Cryopyrin-Associated Periodic Syndrome were promoted by the extracellular presence of the inflammasome adaptor protein ASC, opening exciting new directions in clinical practice to obtain a novel therapy towards secondary amyloidosis in inflammasomopathies.

To uncover the mechanism of fibroproliferative tissue formation in early-stage fibrodysplasia ossificans progressiva (FOP), mesenchymal stromal cells (MSCs) from patient-derived induced pluripotent stem cells and FOP model mice carrying the human ACVR1 (R206H) allele were examined.

Q. Yuan and Q. Li discuss a potential therapeutic strategy for fibrodysplasia ossificans progressiva as reported by M. Ikeya and colleagues, in this issue of EMBO Mol Med.

This study provides the first evidence of a causal relationship between bi-allelic variants in the WDR47 gene and a complex neurodevelopmental syndrome characterized by corpus callosum dysgenesis (CCD), microcephaly and other neuroanatomical phenotypes in both humans and mice.

In this review, PC Yang and colleagues discuss the role of air pollution, particularly the fine particulate matter PM2.5, in lung carcinogenesis.

The liver function in post-cardiac arrest brain injury is not known and was investigated in a pig model of global cerebral ischemia.

The availability of intracellular polyunsaturated fatty acids depends on FADS1/2 desaturases, expressed at higher levels in aggressive triple-negative breast cancers highly susceptible to ferroptosis.

In the circulation, platelets interact with blood monocytes enhancing their inflammatory capacity. Platelets are enriched in transcriptional regulators that support human monocyte inflammation. Thrombocytopenia, experimentally induced or as a result of autoimmune disease, renders monocytes anergic to immune stimulation, a state known as immunoparalysis, which weakens host defense programs and increases susceptibility to infection.

Highly specific antibodies against the extracellular domain of LGR5 were developed as (i) a research tool to study LGR5 biology, (ii) for diagnostic use in multiple cancer types and (iii) as novel immunotherapeutics.

The fat mass and obesity-associated (FTO) protein, an N⁶-methyladenosine (m⁶A) demethylase, influences endothelial cell (EC) function and retinal homeostasis in diabetic retinopathy (DR), thus providing a promising nanotherapeutic approach for DR.

At high density and in tumours TNBC cells produce MUFAs via SCD and secrete lipid-bound MUFAs that protects them from pro-ferroptotic lipid peroxidation. TNBC cells metastasizing in the bloodstream downregulate SCD expression that sensitizes them to the inhibition of Sec-tRNAsec biosynthesis.

A potent small molecule TSLPR inhibitor was identified as a novel therapeutic option for atopic diseases.

In the early phase of Alzheimer’s disease, astrocytes are the primary source of APOE in the brain. This study examined the effects of astrocyte-derived human APOE isoforms in APOE-deficient mouse brains on amyloid pathology and related cellular responses.