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New work finds the syncytia formation in lungs that is associated with severe forms of coronavirus disease to be enhance upon infection with recently emerged alpha, beta and delta viral variants.
An unexpected role for caspase-5 in promoting bacterial cytosolic LPS release links LPS sensing to epithelial cell layer integrity via regulation of E-cadherin expression.
Acute cold stimulates thermogenesis in murine beige adipocytes by triggering β2 adrenergic receptor-dependent secretion of acetylcholine from a subpopulation of adipose macrophages.
Spike protein mutations expressed by emerging SARS-CoV-2 variants-of-concern differentially affect host cell-to-cell fusion, ACE2 receptor binding, and antibody escape.
A PIKfyve/caspase-5/Lyn cascade downregulating E-cadherin expression downstream of sorting nexin 10 provides a potential pharmacological target for inflammatory bowel disease caused by intestinal microbiome alterations.
Adipocyte energy dissipation is fueled by the non-essential amino acid asparagine via an mTORC1-4E-BP1-glycolysis axis.
The immune-checkpoint receptor/ligand pair PD-1/PD-L1 sustains phagocytic function of microglia to prevent Aβ plaque deposition in APP/PS mouse models and patient tissues.
A screen for repressors of cholera toxin production identifies VcdPR as the first V. cholerae RNA that acts both as a non-coding expression modulator and by encoding a small protein.
Restriction of pre-dawn plant growth gene expression is regulated by post-translational modification of the diurnal transcription factor TOC1.
Differentiation-induced Tsix RNA triggers asymmetric distribution of RIF1 and KAP1 on the future inactive and active mouse X chromosomes, respectively, establishing a self-sustaining Xist expression loop from an initially stochastic event.
An unsuspected UBR7 function in recognition of displaced methylated histones opposes their storage by NASP, instead promoting their reincorporation into chromatin.