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There are many paths into and through academic science. Heran Darwin describes how she eventually got hooked on research.
Caenorhabditis elegans embodies the expectations of a solution-driven take on biology on the one hand, and the mysteries and wonders of life that drives biologists to go to their labs on the other hand.
New media arts take inspiration and tools from new technologies and scientific research. In turn, they have great potential for communication of science and its role for sustainability.
The creation of human blastoids holds great potential for research on early human development but also raises considerations about the ethics of such research and its regulation.
This year's outbreak of avian flu has been the worst ever and prompted much debate and research on developing vaccines for domestic and wild birds.
Microbiomes synthesize or modify multiple bioactive small molecules, which impact their host's physiology. This review highlights key effects of bioactive microbe-associated metabolites and discusses how they may impact mammalian physiology and associated disorders.
The functional importance of the SARS-CoV-2 spike N-terminal domain is poorly understood. This study demonstrates that length variation in flexible loops within the NTD can modulate spike activity to optimise SARS-CoV-2 entry.
Interleukin 27 is a heterodimeric cytokine that elicits potent immuno-suppressive responses. The structure of the IL-27 signalling complex provides a mechanistic blueprint to fine-tune IL-27 immuno-modulatory activities.
Repeated migration of cancer cells through constrictions leads to a population of cells with stably altered cellular, nuclear, and migratory phenotypes. These cells have alterations in 3D chromosome organization, including reorganization of chromatin compartments.
Lint-O, a novel L(3)mbt interactor, cooperates with L(3)mbt to suppress piRNA amplification genes and other gene targets to maintain homeostasis in Drosophila ovary and brain.
Dipeptidyl peptidase 9 triggers BRCA2 degradation and promotes repair of DNA double strand breaks by homologous recombination.
Canonical inflammasomes in neutrophils promote caspase-1-dependent cleavage of proIL-1β and GSDMD. GSDMD mediates the secretion of IL-1β and canonical inflammasome-induced neutrophil pyroptosis, whereas GSDMD is dispensable for NETosis induction by the phorbol ester PMA.
High temperature and photoreceptor phytochrome B antagonistically modulate the S-nitrosylation level of HFR1 to coordinate seed germination.
Stress-mediated upregulation of bipolar-disorder-associated miR-499-5p in rat hippocampal neurons leads to impaired surface expression of L-type calcium channels, defective neuroplasticity, and short-term memory impairments.
The CDK9 kinase and PP2A phosphatase are known to act at the early elongation checkpoint (EEC). This work shows that CDK9 and PP2A activities are also required at the 3′ end of genes to couple transcription termination and RNA maturation.
Translation elongation factor eEF2 maintains de novo synthesis of proteins including GluA2 in excitatory neurons of the medial prefrontal cortex, thus promoting AMPAR-mediated excitatory synaptic transmission for normal social novelty behavior.
A RAB6-Dynein-LIS1 complex controls post-Golgi apical transport of CRUMBS in neuronal progenitors. Impairment of this pathway alters apical junctions, causes delamination of these epithelial cells, and leads to the formation of basal progenitors.
UBXD8 is a mammalian VCP adaptor that dually localizes to mitochondria and the ER to mediate mitochondria- and ER-associated protein degradation. UBXD8 facilitates the degradation of mitochondrial substrates to restrain apoptosis and mitophagy.
The Notch ligand Jag2b mediates the neuron-to-glia crosstalk to ensure the irreversible differentiation of Müller glial cells, providing novel mechanistic insights into the temporal specification of glial cell fate in the developing vertebrate retina.
This study presents a method for prospectively isolating HSCs from in vitro cultures. Paired molecular and functional analyses on a large number of individual clones identifies a gene expression signature that can identify functional HSCs from multiple cellular states.