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Table of contents

Volume 23Issue 106 October 2022

    Opinion

    Opinion14 September 2022
    The mind of a scientist
    Description unavailable

    There are many paths into and through academic science. Heran Darwin describes how she eventually got hooked on research.

    Science & Society

    Science & Society10 August 2022
    SDGs in new‐media arts for science: How do new‐media arts promote biotech as means for sustainable development?
    Description unavailable

    New media arts take inspiration and tools from new technologies and scientific research. In turn, they have great potential for communication of science and its role for sustainability.

    Science & Society12 September 2022
    Keep biology weird: On disobedient worms and scientific freedom
    Description unavailable

    Caenorhabditis elegans embodies the expectations of a solution‐driven take on biology on the one hand, and the mysteries and wonders of life that drives biologists to go to their labs on the other hand.

    Science & Society14 September 2022
    The regulation of human blastoid research: A bioethical discussion of the limits of regulation
    Description unavailable

    The creation of human blastoids holds great potential for research on early human development but also raises considerations about the ethics of such research and its regulation.

    Science & Society14 September 2022
    Europe's worst ever bird flu outbreak: Thus year's epidemic of highly pathogenic avian flu has had a devastating impact on wild and domestic birds and severe economic consequences
    Description unavailable

    This year's outbreak of avian flu has been the worst ever and prompted much debate and research on developing vaccines for domestic and wild birds.

    Review

    Review29 August 2022
    Local and systemic effects of microbiome‐derived metabolites
    Description unavailable

    Microbiomes synthesize or modify multiple bioactive small molecules, which impact their host's physiology. This review highlights key effects of bioactive microbe‐associated metabolites and discusses how they may impact mammalian physiology and associated disorders.

    Articles

    Article15 August 2022
    Constricted migration is associated with stable 3D genome structure differences in cancer cells
    Description unavailable

    Repeated migration of cancer cells through constrictions leads to a population of cells with stably altered cellular, nuclear, and migratory phenotypes. These cells have alterations in 3D chromosome organization, including reorganization of chromatin compartments.

    Article22 August 2022
    Lint‐O cooperates with L(3)mbt in target gene suppression to maintain homeostasis in fly ovary and brain
    Description unavailable

    Lint‐O, a novel L(3)mbt interactor, cooperates with L(3)mbt to suppress piRNA amplification genes and other gene targets to maintain homeostasis in Drosophila ovary and brain.

    Article28 July 2022
    GSDMD drives canonical inflammasome‐induced neutrophil pyroptosis and is dispensable for NETosis
    Description unavailable

    Canonical inflammasomes in neutrophils promote caspase‐1‐dependent cleavage of proIL‐1β and GSDMD. GSDMD mediates the secretion of IL‐1β and canonical inflammasome‐induced neutrophil pyroptosis, whereas GSDMD is dispensable for NETosis induction by the phorbol ester PMA.

    Article5 September 2022
    Phytochrome B enhances seed germination tolerance to high temperature by reducing S‐nitrosylation of HFR1
    Description unavailable

    High temperature and photoreceptor phytochrome B antagonistically modulate the S‐nitrosylation level of HFR1 to coordinate seed germination.

    Article15 August 2022
    Article18 August 2022
    CDK9 and PP2A regulate RNA polymerase II transcription termination and coupled RNA maturation
    Description unavailable

    The CDK9 kinase and PP2A phosphatase are known to act at the early elongation checkpoint (EEC). This work shows that CDK9 and PP2A activities are also required at the 3′ end of genes to couple transcription termination and RNA maturation.

    Article22 August 2022
    eEF2 in the prefrontal cortex promotes excitatory synaptic transmission and social novelty behavior
    Description unavailable

    Translation elongation factor eEF2 maintains de novo synthesis of proteins including GluA2 in excitatory neurons of the medial prefrontal cortex, thus promoting AMPAR‐mediated excitatory synaptic transmission for normal social novelty behavior.

    Article18 August 2022
    RAB6 and dynein drive post‐Golgi apical transport to prevent neuronal progenitor delamination
    Description unavailable

    A RAB6‐Dynein‐LIS1 complex controls post‐Golgi apical transport of CRUMBS in neuronal progenitors. Impairment of this pathway alters apical junctions, causes delamination of these epithelial cells, and leads to the formation of basal progenitors.

    Article18 August 2022
    UBXD8 mediates mitochondria‐associated degradation to restrain apoptosis and mitophagy
    Description unavailable

    UBXD8 is a mammalian VCP adaptor that dually localizes to mitochondria and the ER to mediate mitochondria‐ and ER‐associated protein degradation. UBXD8 facilitates the degradation of mitochondrial substrates to restrain apoptosis and mitophagy.

    Article1 September 2022
    Jag2b‐Notch3/1b‐mediated neuron‐to‐glia crosstalk controls retinal gliogenesis
    Description unavailable

    The Notch ligand Jag2b mediates the neuron‐to‐glia crosstalk to ensure the irreversible differentiation of Müller glial cells, providing novel mechanistic insights into the temporal specification of glial cell fate in the developing vertebrate retina.

    Article3 August 2022
    Structural insights into the assembly and activation of the IL‐27 signaling complex
    Description unavailable

    Interleukin 27 is a heterodimeric cytokine that elicits potent immuno‐suppressive responses. The structure of the IL‐27 signalling complex provides a mechanistic blueprint to fine‐tune IL‐27 immuno‐modulatory activities.

    Article16 August 2022
    Identification and characterization of in vitro expanded hematopoietic stem cells
    Description unavailable

    This study presents a method for prospectively isolating HSCs from in vitro cultures. Paired molecular and functional analyses on a large number of individual clones identifies a gene expression signature that can identify functional HSCs from multiple cellular states.