Don’t fool yourself to think that you are safe from emails just because you enabled the “Out of office” function. It is not an ‘Off’ button that grants you reprieve from daily chores.

How many PhD students per PI is the optimal number?

Boredom is a unique human emotion. Understanding its causes and consequences and how people learn to cope with it to develop new ideas and inspiration could help to alleviate its negative effects.

Science gifts us the tools to solve the pressing humanitarian and ecological challenges of our time. But ignorance and selfishness prevent us from using science to the best effect.

Scientific research is increasingly becoming datafied through the use of electronic lab notebooks and smart instruments. This has significant implications for surveillance at work and research itself.

Two-photon imaging reveals the spatiotemporal regulation of pollen tube guidance based on multistep blocking systems to prevent polyspermy.

TMEM268 interacts with the β2 integrin subunit CD11b and attenuates its degradation via the endosome–lysosome pathway, thereby promoting phagocyte adhesion, migration, phagocytosis and bacterial clearance during sepsis.

Auxin triggers NBR1-mediated selective autophagic degradation of ARF7 to modulate periodic root branching in Arabidopsis.

Depleting the cachectic factor IL-6 from tumors increases tumor immune infiltration and slows down tumor growth, but it does not prevent cachexia although circulating IL-6 is not elevated.

Syt11 facilitates the assembly of GABA_B/Cav2.2 components into a signaling complex in post-Golgi vesicles prior to their delivery to the presynaptic membrane, where this complex then regulates neurotransmitter release.

The p38 pathway regulates T cell-mediated adipose tissue inflammation and browning via IL-35. Lack of p38 activation in T cells increases IL-35, thereby inducing thermogenesis and reducing inflammation.

RNA-binding protein hnRNPL is crucial for proliferation, survival, and metabolism during B cell activation, and boosts antibody responses. hnRNPL regulates conserved alternative splicing events of epigenetic modifiers to maintain epigenetic and transcriptional programs.

In C. elegans, a critical step in centriole assembly involves phosphorylation of the centriole scaffold protein SAS-5 by ZYG-1, which is required for recruitment of SAS-4 and the stable incorporation of the SAS-5-SAS-6 complex into the nascent centriole.

Epsilon tubulin functions within several microtubule-dependent processes during spermatogenesis such as meiotic division, sperm tail axoneme stability, and manchette-mediated sperm head shaping.

Overexpression of the mitotic checkpoint complex component MAD2 causes myelosuppression and gastrointestinal atrophy due to excessive apoptosis. Loss of pro-apoptotic Bim/Bcl2l11 preserves gut homeostasis but not hematopoiesis, indicating tissue-specific survival dependencies.

ERAD dysfunction activates compensatory ERLAD programs to clear misfolded ER proteins.

Digital Holographic Microscopy (DHM) detects membraneless biomolecular condensates and membrane-bound organelles without staining.