Single-Molecule Footprinting reveals that RNA polymerase II (Pol II) occupancy is infrequent at mouse promoters. This results from a combination of higher Pol II turnover and lower transcription initiation at mouse compared to Drosophila promoters.

Mathematical modeling reveals how population size, genetic architecture, and pleiotropic constraints shape the evolution of gene product diversity, providing a quantitative framework for distinguishing between adaptive and non-adaptive explanations for the existence of multiple isoforms of a gene.

Multi-epitope immunopurifications of huntingtin (HTT) from vulnerable brain regions of Huntington’s disease (HD) models identify disease-linked protein interaction networks, capturing HD cell biology across pathways and subcellular compartments.